Impulse blockade in frog cardiac ganglion does not resemble partial denervation in changing synaptic organization

Science  06 Oct 1978:
Vol. 202, Issue 4363, pp. 66-68
DOI: 10.1126/science.308697


Partial denervation of parasympathetic neurons in the frog heart by surgical section of one vagus nerve results in a marked reorganization of functional synaptic connections made by the remaining vagus nerve. These changes are not simply due to a lack of impulse activity per se in the sectioned nerve because blockage of impulses in one vagus with tetrodotoxin-impregnated cuffs did not cause similar changes in the innervation pattern of the ganglion. Furthermore, tetrodotoxin-blocked vagal fibers retain their ability to sprout and can form new synapses on denervated neurons.