Vitamin D3-induced calcium binding protein in bone tissue

See allHide authors and affiliations

Science  06 Oct 1978:
Vol. 202, Issue 4363, pp. 70-71
DOI: 10.1126/science.211584


As detected by radioimmunoassay with antiserums against chick intestinal calcium binding protein (CaBP), administration of vitamin D3 to rachitic chicks causes a 25- to 100-fold increase in immunoreactive CaBP in chick bone. The bone CaBP has a higher molecular weight (approximately 34,000 daltons) than intestinal CaBP (28,000 daltons), is concentrated principally in the spongiosa and cartilage plate regions of tibia, and responds adaptively to reflect the level of dietary calcium.