Reports

beta-Endorphin is not detectable in plasma from normal human subjects

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Science  13 Oct 1978:
Vol. 202, Issue 4364, pp. 221-223
DOI: 10.1126/science.211585

Abstract

beta-Endorphin is not detectable in plasma from normal human subjects when measured under baseline conditions or after the subjects have received vasopressin, an agent that elevates beta-lipotropin and adrenocorticotropic hormone (ACTH). Significant amounts of beta-endorphin are present in plasma of patients with endocrine disorders associated with increased ACTH and beta-lipotropin production. Highly purified, natural beta-lipotropin is not peripherally converted to beta-endorphin in vivo in normal subjects.