Cocaine plasma concentration: relation to physiological and subjective effects in humans

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Science  13 Oct 1978:
Vol. 202, Issue 4364, pp. 227-228
DOI: 10.1126/science.694530


Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.