Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro

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Science  27 Oct 1978:
Vol. 202, Issue 4366, pp. 438-440
DOI: 10.1126/science.705337


Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.