S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity

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Science  17 Nov 1978:
Vol. 202, Issue 4369, pp. 757-760
DOI: 10.1126/science.715439


When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.