Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex

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Science  17 Nov 1978:
Vol. 202, Issue 4369, pp. 768-770
DOI: 10.1126/science.102031


When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon.