Kainic acid injections result in degeneration of cochlear nucleus cells innervated by the auditory nerve

See allHide authors and affiliations

Science  08 Dec 1978:
Vol. 202, Issue 4372, pp. 1087-1089
DOI: 10.1126/science.31000


When kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. The rate and extent of degeneration is correlated with the distribution of the primary auditory fibers. This evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers.