Transient synapses in the embryonic primate spinal cord

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Science  15 Dec 1978:
Vol. 202, Issue 4373, pp. 1206-1209
DOI: 10.1126/science.103200


Electron microscopic and tritiated thymidine autoradiographic analysis of the embryonic spinal cord in the rhesus monkey reveals considerable rearrangement of cellular and synaptic relationships in the posterior (sensory) quadrant during early developmental stages. This remodeling involves the death of an entire population of neurons that received synapses from sensory afferent axons and the possible relocation of these afferents upon subsequently generated viable substantia gelatinosa neurons.