N-acetyl gramicidin: single-channel properties and implications for channel structure

See allHide authors and affiliations

Science  05 Jan 1979:
Vol. 203, Issue 4375, pp. 55-57
DOI: 10.1126/science.83000


Substitution of a methyl group for the N-terminal hydrogen of gramicidin greatly increased the rate of dissociation of conductive channels in lipid bilayer membranes. The finding of short lifetimes for conductive channels, comparable to those seen for the neuromuscular junction, lends support to the head-to-head dimer structure for the conductive channel.