Mammary cancer: selective action of the estrogen receptor complex

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Science  26 Jan 1979:
Vol. 203, Issue 4378, pp. 361-363
DOI: 10.1126/science.760195


Progesterone receptors in the autonomous rat mammary tumor MTW-9B are reduced 80 to 90 percent after ovariectomy, but are not reduced if ovariectomized animals are given estrogen. Tumor growth, however, is independent of estrogen status and insensitive to pharmacological doses of estradiol. This represents an unusual system characterized by a selective action of an inducing agent on the genome.