Eye malformations in rats: induction by prenatal exposure to nickel carbonyl

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Science  09 Feb 1979:
Vol. 203, Issue 4380, pp. 550-553
DOI: 10.1126/science.104388


Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.