Fertilization: a uterine glycosaminoglycan stimulates the conversion of sperm proacrosin to acrosin

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Science  09 Feb 1979:
Vol. 203, Issue 4380, pp. 553-554
DOI: 10.1126/science.32621


Acrosin is a proteinase required for mammalian fertilization, and in freshly ejaculated spermatozoa exists as an inactive zymogen, proacrosin. A factor prsent in uterine flushings of gilts stimulates the conversion of highly pruified boar proacrosin to acrosin. Characterization of this factor indicates that its active component is a glycosaminoglycan.