A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity

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Science  09 Feb 1979:
Vol. 203, Issue 4380, pp. 554-556
DOI: 10.1126/science.760204


A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.