Chemical Characterization of a Hormone That Promotes Cell Arrest in G2 in Complex Tissues

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Science  16 Mar 1979:
Vol. 203, Issue 4385, pp. 1122-1123
DOI: 10.1126/science.203.4385.1122


A G2|factor in the cotyledons of Pisum sativum, which arrests the growth of cells in both roots and shoots in the G2 stage of the cell cycle, has been isolated and identified as trigonelline (N-methylnicotinic acid). To our knowledge, trigonelline is the first hormone that effects cell arrest in complex tissues of plants and animals to be chemically identified.