Control of oscillations in hematopoiesis

See allHide authors and affiliations

Science  30 Mar 1979:
Vol. 203, Issue 4387, pp. 1348-1349
DOI: 10.1126/science.284587


Results of a mathematical analysis of models of hematopoietic systems introduced by Mackey and Glass are given. The models include a constant time lag, and it is shown that this lag has a critical value above which oscillations in blood cell concentration occur. To reduce the likelihood of disease associated with such oscillations, physiologists should seek to learn how to increase this critical value of the lag.