Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors

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Science  13 Apr 1979:
Vol. 204, Issue 4389, pp. 188-191
DOI: 10.1126/science.432641


Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to 42 degrees C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.