Rank order of sarcoma susceptibility among mouse strains reverses with low concentrations of carcinogen

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Science  20 Apr 1979:
Vol. 204, Issue 4390, pp. 309-310
DOI: 10.1126/science.432644


Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.