Iron deficiency prevents liver toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Science  20 Apr 1979:
Vol. 204, Issue 4390, pp. 332-335
DOI: 10.1126/science.432648


The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.