Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease

See allHide authors and affiliations

Science  11 May 1979:
Vol. 204, Issue 4393, pp. 624-626
DOI: 10.1126/science.432666


A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrsopinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed.