Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus

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Science  25 May 1979:
Vol. 204, Issue 4395, pp. 843-844
DOI: 10.1126/science.220707


Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.