Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis

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Science  25 May 1979:
Vol. 204, Issue 4395, pp. 854-855
DOI: 10.1126/science.375393


Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.