Normal anterior endoderm corrects the heart defect in cardiac mutant salamanders (Ambystoma mexicanum)

Science  25 May 1979:
Vol. 204, Issue 4395, pp. 860-862
DOI: 10.1126/science.441740


Recessive mutant gene c in axolotl embryos results in an absence of heart function. Normal (+/+) anterior endoderm cultured with mutant (c/c) hearts totally corrects the defect.