Transmitter-specific retrograde labeling in the striato-nigral and raphe-nigral pathways

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Science  20 Jul 1979:
Vol. 205, Issue 4403, pp. 306-308
DOI: 10.1126/science.451602


Injecting radioactive transmitters into the rat substantia nigra led to retrograde neuronal labeling either in the dorsal raphe nucleus, after 3H-labeled serotonin injection, or in the caudoputamen, after 3H-labeled gamma-aminobutyric acid injection. This differential labeling in projections whose transmitter has been established provides the basis for a histochemical tracing method indicating both connectivity and transmitter specificity of neural pathways.