Stress and coping factors influence tumor growth

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Science  03 Aug 1979:
Vol. 205, Issue 4405, pp. 513-515
DOI: 10.1126/science.109924


Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated as a result of various stress regimens. A single session of inescapable shock resulted in earlier tumor appearance, exaggeration of tumor size, and decreased survival time in recipient animals. Escapable shock had no such effects. The effects of the inescapable shock were mitigated if mice received long-term shock treatment.