6-Hydroxydopamine potentiates acute herpes simplex virus infection of the superior cervical ganglion in mice

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Science  03 Aug 1979:
Vol. 205, Issue 4405, pp. 518-520
DOI: 10.1126/science.221984


Treatment of mice with 6-hydroxydopamine increased herpes simplex virus replication in the superior cervical ganglion while it decreased the subsequent prevalence of latent infection. Preganglionic neurectomy failed to block this effect. These observations suggest that intrinsic neural events modify the outcome of viral infections of the nervous system.