Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

Science  10 Aug 1979:
Vol. 205, Issue 4406, pp. 598-600
DOI: 10.1126/science.451624


Serum thyroxine levels peak earlier and are significantly higher in audiogenic seizure-susceptible DBA/2J mice than in seizure-resistant C57BL/6J mice during early postnatal life. The seizure susceptibility of DBA/2J mice is suppressed by administration of an antithyroid drug or by radiothyroidectomy, while the seizure susceptibility of C57BL/6J mice is enhanced by treatment with excess thyroxine.