5-Bromodeoxyuridine inhibits sequence changes within inverted repeat DNA during embryogenesis

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Science  24 Aug 1979:
Vol. 205, Issue 4408, pp. 816-818
DOI: 10.1126/science.572583


Previous studies on the genome of Strongylocentrotus purpuratus sea urchin have shown that changes in the nucleotide sequence of inverted repeat sequences occur during embryogenesis. The present study indicates that these sequence changes fail to occur when the embryos are raised in the presence of 5-bromodeoxyuridine. This drug is an analog of thymidine, is incorporated into the DNA during embryogenesis, and inhibits cell differentiation in these embryos.