Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation

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Science  24 Aug 1979:
Vol. 205, Issue 4408, pp. 823-825
DOI: 10.1126/science.462193


Menopausal flush episodes were found to be invariably associated with the initiation of pulsatile pituitary release of luteinizing hormone. This was not accompanied by a significant change in circulating catecholamine or prolactin concentrations. Since pulsatile luteinizing hormone release results from episodic secretion of luteinizing hormone releasing factor by the hypothalamus, these findings suggest a link between the neuroendocrine mechanisms that initiate such episodic secretion and those responsible for the onset of flush episodes.