Insulin receptor binding in obesity: a reassessment

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Science  07 Sep 1979:
Vol. 205, Issue 4410, pp. 1003-1004
DOI: 10.1126/science.472718


A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo--as it does in vitro.