Saccharin metabolism and tumorigenicity

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Science  07 Sep 1979:
Vol. 205, Issue 4410, pp. 1019-1020
DOI: 10.1126/science.472722


Exposure of male Charles River CDI rats to a 5% saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (less than 0.4% of the oral dose) of tritiated saccharin in vivo. No metabolites (less than 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.