Iodine-125--labeled estradiol: a gamma-emitting analog of estradiol that binds to the estrogen receptor

See allHide authors and affiliations

Science  14 Sep 1979:
Vol. 205, Issue 4411, pp. 1138-1140
DOI: 10.1126/science.472733


17 beta-[16 alpha-125I]Iodoestradiol has been synthesized by exchange of 16 beta-bromoestradiol with Na125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro.