[3H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids?

See allHide authors and affiliations

Science  14 Sep 1979:
Vol. 205, Issue 4411, pp. 1147-1149
DOI: 10.1126/science.224459


Binding sites for tritum-labeled gamma-aminobutyric acid (GABA) in cerebellar cortex of Huntington's chorea patients have an increased affinity but unaltered maximum capacity as compared to binding sites in tissue from control patients. A similar binding pattern is produced in control membranes by treatment with Triton X-100, phospholipase C, or glycerophosphoethanolamine. Thus, it is likely that phospholipids or their metabolites regulate the accessibility of the GABA binding site and that this regulation is abnormal in Huntington's chorea.