Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist

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Science  14 Sep 1979:
Vol. 205, Issue 4411, pp. 1151-1153
DOI: 10.1126/science.382359


Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.