DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro

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Science  21 Sep 1979:
Vol. 205, Issue 4412, pp. 1281-1282
DOI: 10.1126/science.472744


High-resolution autoradiography and fine structural analysis of adult newt heart tissue in long-term culture revealed that tritiated thymidine was concentrated in the nuclei of dedifferentiated myocardial cells. Mitotic chromosomes were observed in some of these cells. This demonstrates that adult amphibian myocardial cells in vitro are capable of DNA synthesis and mitosis.