Reports

Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons

See allHide authors and affiliations

Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1409-1412
DOI: 10.1126/science.224464

Abstract

Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.