Perinatal exposure to cannabinoids alters male reproductive function in mice

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Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1420-1422
DOI: 10.1126/science.472762


Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.