Tyrosine hydroxylase immunoreactivity in familial dysautonomia

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Science  05 Oct 1979:
Vol. 206, Issue 4414, pp. 71-72
DOI: 10.1126/science.39339


Tyrosine hydroxylase antigen was localized immunohistochemically in sympathetic neurons from human autopsy tissue. The reaction persists in paraffin-embedded tissue, and the method is applicable to archival specimens. Increased amounts in this antigen per cell may partially compensate for decreased numbers of sympathetic neurons in familial dysautonomia.