Shark heart mitochondria: effects of external osmolality on respiration

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Science  05 Oct 1979:
Vol. 206, Issue 4414, pp. 75-76
DOI: 10.1126/science.482928


Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.