Inhibition of histaminase release from human granulocytes by products of histaminase activity

See allHide authors and affiliations

Science  05 Oct 1979:
Vol. 206, Issue 4414, pp. 77-78
DOI: 10.1126/science.113872


Imidazoleacetic acid, a product of the action of histaminase (E.C. on histamine, inhibits specific release of histaminase from human peripheral blood granulocytes with an inhibition constant between 5 X 10(-9)M and 1 X 10(-8)M. Hence, modulation of enzyme release is indirectly mediated by the activity of the enzyme.