Effect of beta-endorphin on calcium uptake in the brain

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Science  05 Oct 1979:
Vol. 206, Issue 4414, pp. 89-91
DOI: 10.1126/science.39340


The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.