Calmodulin activation of adenylate cyclase in pancreatic islets

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Science  12 Oct 1979:
Vol. 206, Issue 4415, pp. 225-227
DOI: 10.1126/science.225798


Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.