Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia

See allHide authors and affiliations

Science  26 Oct 1979:
Vol. 206, Issue 4417, pp. 481-483
DOI: 10.1126/science.228392


A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.