Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum

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Science  02 Nov 1979:
Vol. 206, Issue 4418, pp. 577-580
DOI: 10.1126/science.493963


D-Arabinitol was identified as a major metabolite of Candida species in human subjects. Gas-liquid chromatography was used to measure the concentration of D-arabinitol in serum. The study included subjects who were healthy and cancer patients who had proven invasive candidiasis or were colonized with Candida. D-Arabinitol concentrations greater than 1.0 microgram per milliliter were found in serum from patients with invasive infection. This technique may prove valuable in the diagnosis of invasive candidiasis.