Phase resetting and annihilation of pacemaker activity in cardiac tissue

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Science  09 Nov 1979:
Vol. 206, Issue 4419, pp. 695-697
DOI: 10.1126/science.493975


Spontaneous rhythmic activity in isolated cardiac pacemaker cells can be terminated by a brief, subthreshold, depolarizing or hyperpolarizing perturbation of the proper magnitude applied at a specific point in the pacemaker cycle. Evidence is provided in support of a topological theory of the existence of a "singular" point in cardiac oscillators.