Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy

Science  16 Nov 1979:
Vol. 206, Issue 4420, pp. 844-847
DOI: 10.1126/science.493985


Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.