Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen

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Science  04 Jan 1980:
Vol. 207, Issue 4426, pp. 68-71
DOI: 10.1126/science.6965328


Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals.