Doridosine: a new hypotensive N-methylpurine riboside from the nudibranch Anisodoris nobilis

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Science  11 Jan 1980:
Vol. 207, Issue 4427, pp. 193-195
DOI: 10.1126/science.7350655


A new N-methylpurine riboside (doridosine), probably N1-Methylisoguanosine, was isolated from the digestive glands of a nudibranch. Doridosine produces prolonged hypotension and bradycardia in anesthetized rats, decreases the rate and the amplitude of contraction of guinea pig atria in vitro, and causes the heart rate in anesthetized mice to be reduced by 50 percent for many hours after which the animals recover completely.