beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system

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Science  08 Feb 1980:
Vol. 207, Issue 4431, pp. 645-647
DOI: 10.1126/science.6101510


Incubation of rat cerebral cortical slices with the beta-adrenergic agonist isoproterenol causes an increase in alpha 2-adrenergic receptor binding in addition to a decrease in beta-adrenergic receptor binding. The effects are rapid and reversible, show a parallel time course, and are blocked by sotalol, a beta-adrenergic receptor antagonist. The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.