gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro

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Science  08 Feb 1980:
Vol. 207, Issue 4431, pp. 653-655
DOI: 10.1126/science.6101511


The endothelia of microvessels isolated from mouse brain by mechanical means are rich in gamma-glutamyl transpeptidase; however, the enzyme often disappears when the cells migrate or proliferate from the microvessel isolates. In an endothelial cell line derived from similar isolates and negative for gamma-glutamyl transpeptidase, the enzyme could be induced in the endothelial cells when they were cocultured with glial cells. Thus there may be a requirement for continuous induction of gamma-glutamyl transpeptidase in brain microvessels by adjacent glial cells.